Recent progress on the role and molecular mechanism of chicken ovalbumin upstream promoter-transcription factor II in cancer

Recent progress on the role and molecular mechanism of chicken ovalbumin upstream promoter-transcription factor II in cancer

Blog Article

Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) is an orphan receptor that regulates the expression of genes involved in development and homeostasis.COUP-TFII is also dysregulated in cancer, where it plays important roles in oncogenesis and malignant progression.Recent studies have also investigated altered microRNA-mediated regulation of COUP-TFII in cancer.Although many investigators have studied the Suction Therapy Accessories expression and clinical significance of COUP-TFII in several cancer types, there remain many controversies regarding its role in these diseases.In this review, we will describe the functions and underlying molecular LIP SHIMMER PEONY mechanisms of COUP-TFII in several cancers, especially colorectal, gastric, breast, and prostate cancer; additionally, we will briefly summarize what is known about microRNA-mediated regulation of COUP-TFII.